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The Fioravante laboratory investigates how foundational neural primitives including stimulus value (valence), acquired strength (salience) and prediction are computed by mammalian microcircuits to support learned behavior. We focus on the cerebellum, the brain’s “prediction machine”, the non-motor functions of which lack mechanistic understanding. We dissect long-range cerebellar circuits that signal to the prefrontal cortex, the nucleus accumbens and the amygdala and dissect their role in cognition, affect and reinforcement learning

By dissecting the operating principles of novel cerebello-limbic circuits and their synaptic and molecular elements, we shed light on their functionality and aspire to explain how their perturbations contribute to brain disorders. Our research has the potential to revise long-held views on how emotion- and reward-relevant operations are modulated in the mammalian brain and has implications for anxiety, PTSD, addiction and autism spectrum disorders.

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Our toolbox includes transgenic mice, optogenetics, ex vivo patch-clamp and in vivo large-scale electrophysiology, calcium imaging, Patch-seq and animal behavior assays. With these tools at hand, we aim to bridge the knowledge gap between synaptic, cellular and circuit levels of analysis.

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Principle Investigator:

Diasynou Fioravante, PhD

Associate Professor 

Dept. of Neurobiology, Physiology and Behavior

Core Faculty, Center for Neuroscience

Affiliate Faculty, Institute for Psychedelics and Neurotherapeutics

Affiliate Faculty, Center for Neuroengineering and Medicine

Member, Neuroscience Graduate Group

Member, Biomedical Engineering Graduate Group

 

Mailing/Shipping Address: 

Diasynou Fioravante

UC Davis Center for Neuroscience

Med Neuro Building 409/605/609

1544 Newton Court

Davis, CA 95618

 

Lab: (530) 754 7382

Office: (530) 752 1887

email: dfioravante at ucdavis dot edu

www.fioravantelab.ucdavis.edu

Pronouns: she/her/hers

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